AOD-9604 2mg

AOD9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (HGH), studied in laboratory research for its effects on fat metabolism pathways.¹ Research referenced here includes both in vitro (cell-based) and animal (in vivo) laboratory studies exploring the effects of AOD9604 on fat cells, metabolic pathways, and cartilage-related cell activity.

Fat Metabolism Research

In laboratory studies, AOD9604 has been shown to promote lipolysis (breakdown of stored fat) in cultured adipocytes (fat cells) and influence the expression of genes related to fat metabolism.³ Animal studies have also examined fat oxidation and weight changes following chronic administration in mouse models.² These findings are exploratory laboratory observations and do not establish efficacy for any application outside of controlled research.

Glucose Metabolism Research

Laboratory research has evaluated AOD9604’s effects on glucose uptake and insulin sensitivity in cultured muscle cell models.¹

Cartilage Cell Research

Animal model studies have examined AOD9604’s effects on cartilage-related cell activity, including intra-articular injection studies in rabbit models assessing collagen and proteoglycan production, as well as markers of inflammatory signaling in joint tissue.^4,5 These studies were designed to investigate mechanisms of joint tissue biology in animal models and do not establish safety or efficacy for any human or animal application.

Cell Toxicity Screening

A laboratory study assessed AOD9604 for toxicity across various cultured cell types and reported no cytotoxic effects in the cell lines tested.⁶ This is a preliminary in vitro finding and does not establish safety for human or animal use.

Important Note

These findings are based exclusively on in vitro and animal laboratory research. This product is not intended for human or animal use or consumption, and has not been evaluated for safety or efficacy in humans or animals outside of controlled laboratory research settings.

Summary

AOD9604 continues to be studied in vitro and in animal models for its effects on fat metabolism, glucose uptake, and cartilage-related cell activity. Its use remains strictly limited to laboratory research applications.

References

1. Ng FM et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278.
2. Heffernan MA et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-1449.
3. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of AOD9604 on growth and fat metabolism in mice. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-507.
4. Kwon DR, Park GY. Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in a rabbit osteoarthritis model. Ann Clin Lab Sci. 2015 Summer;45(4):426-432.
5. Kim et al. Additive effects of intra-articular injection of growth hormone and hyaluronic acid in a rabbit model of collagenase-induced osteoarthritis. J Korean Med Sci. 2010 May;25(5):776-780.
6. Moré MI, Kenley D. Safety and metabolism of AOD9604, a novel nutraceutical ingredient for improved metabolic health. J Endocrinol Metab. 2014;4(3):64-77.